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The CAUSE-CRCs will conduct both network-wide and site-specific clinical studies and trials with the ultimate goal of developing effective asthma treatment or prevention approaches applicable to children residing in low-income urban settings. All applications are due by PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date s. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

Conformance to all requirements both in the Application Guide and the FOA is required and strictly enforced. Applicants must read and follow all application instructions in the Application Guide as well as any program-specific instructions noted in Section IV.

When the program-specific instructions deviate from those in the Application Guide, follow the program-specific instructions. Applications that do not comply with these instructions may be delayed or not accepted for review. There are several options available to submit your application through Grants. You must use one of these submission options to access the application forms for this opportunity. NIAID has a long-standing interest in understanding and reducing the disproportionate burden of asthma among children living in low-income urban communities and has funded research initiatives towards this goal over the previous 3 decades.

Previous NIAID-sponsored asthma-related initiatives include: a the National Cooperative Inner City Asthma Study NCICAS, which identified cockroach as a major allergen for urban residents with asthma and demonstrated the effectiveness of an Asthma Counselor intervention; b the Inner City Asthma Study ICAS,which demonstrated the effectiveness of an environmental intervention aimed at reducing allergen exposure among inner-city children; c the Inner City Asthma Consortium I ICAC I,which conducted clinical trials evaluating the biomarker exhaled nitric oxide as a guide for asthma therapy, the use of omalizumab therapy for inner-city children with asthma and established URECA, a birth cohort; d the Inner City Asthma Consortium II ICAC II,which conducted a large asthma phenotyping study, a clinical trial evaluating the use of omalizumab for fall exacerbations, and conducted safety and biomarker trials of cockroach immunotherapy.

The ongoing ICAC III has completed a clinical study determining the transcriptomic signature of asthma exacerbations and is conducting a clinical trial evaluating the effectiveness of mepolizumab among exacerbation prone children with asthma and a trial of cockroach subcutaneous immunotherapy for asthma. The CAUSE Clinical Research Network will conduct observational studies and clinical trials to further improve our understanding of asthma and to develop effective interventions and asthma prevention approaches tailored to children of low-income families living in urban communities.

Other areas of interest include studies that fall under the general objective of elucidating the pathogenesis of asthma or improving the management of asthma in children living in low-income, urban communities and focus on the immune system. These projects can be pilot, non-therapeutic clinical trials or observational studies, clinical mechanistic studies, or laboratory studies utilizing new or existing human biosamples, and should involve junior faculty investigators in key roles.

These projects need to address mechanisms of disease or the management of asthma in children living in low-income urban communities. Note: It is anticipated that at least three network-wide CAUSE clinical projects will be implemented during the course of the awards.

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At least one project will be a clinical trial, while the other projects may be either clinical trials or observational clinical studies. Applications proposing the following topics will be deemed non-responsive and will not be reviewed. In those studies, the NIAID-DAIT data management center s will provide support for the design and organization of the protocol, development of protocol-related materials, data management and quality control, clinical site monitoring, safety monitoring and reporting, data analysis and manuscript development.

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After study initiation, the DSMB will conduct periodic safety reviews. The Steering Committee will also receive information and discuss the progress of individual CAUSE-CRC center-specific research projects, but it will not be involved in the development or implementation of these projects.

Clinical Research Functions : This will involve personnel and facilities capable of conducting network-wide and CAUSE-CRC center-specific research, including trained clinical staff, capabilities of recruiting children and adolescents with asthma who live in low-income urban communities, clinical research facilities, investigational pharmacy services, and laboratory facility capable of processing, storing and shipping human biosamples.

For center-specific research, additional requirements include local biostatistical support, an active, IRB-approved protocol for recruitment and clinical characterization of children with asthma, a data management facility with established data management, quality assurance and control plans, and capability to upload data into the NIAID designated repositories.

CRC Specific Research Projects : Each CAUSE-CRC application should propose one or two center-specific clinical research projects organized around a common theme which could include protocols that test a hypothesis associated with a specific asthma phenotype or endotype with immunologic, epithelial function, allergen exposure, microbiome or other focus of pathophysiologic importance in asthma.

These projects may range from a small non-therapeutic, mechanistic trial to an observational study, or in vitro or ex vivo testing of human biosamples. Studies using only transformed human cell lines will not be considered in scope. Only one small, center-specific clinical trial will be allowed.

Part 1. Overview Information

Only those application types listed here are allowed for this FOA. Need help determining whether you are doing a clinical trial? Non-domestic non-U. Entities Foreign Institutions are not eligible to apply. Organizations are not eligible to apply.

All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.Jump into the right bracket for you! This season is all about making smart moves and we want to help you win big with your finances. Whether its savings, checking or loan, check out our great rates today — so you can celebrate tomorrow!

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Equal Housing Lender.Supersonic sound waves are used to confuse the target. Traps and squeezes the target over two to five turns. The target cannot move while under attack. Has a one-in- five chance of leaving the target with the lingering effects of poison. Instantly forms a barrier between the user and the opponent. A move that makes a horrible noise. However, while it is powerful, it may miss the target. Can normally be used up to three times.

A technique that badly poisons the target. The amount of damage from the poison increases every turn. A charging attack. One quarter of the damage it inflicts comes back to hurt the attacker. A charging tackle attack. An ICE-type attack. Has a one-in-ten chance of freezing the target solid. The strongest ICE-type attack. An extremely powerful attack. The attacker becomes so tired, it has to rest the next turn.

A non-stop attack move. It adds half the HP it drained from the target to the attacker's HP. A move for learning one of the opponent's moves, for use during that battle only. Creates illusionary copies of the user. The copies disorient the enemy, reducing its accuracy. Reduces damage from physical attacks by about half. The user waits for several turns. At the end, it returns double the damage it received. In the first turn, the attacker tucks in its head.

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The next turn, it head-butts at full steam. The user takes a nap to fully restore its HP and recover from any status abnormalities. Also used for cutting small bushes to open new paths. The power of this technique is strong and highly accurate.Special Containment Procedures: SCP is to be kept in a two 2 room cell furnished with all non-organic furniture and items, and a bathroom. Subject is allowed to freely wander the facility and eat in the main canteen. A tracking device has been attached to SCP's person and is not to be removed.

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Subject is disallowed any contact with the surface, and is not allowed outside the facility. Subject is allowed no contact with plant-based SCPs under any circumstances. Violence is not to be used against SCP under any circumstances. Arms, legs, spinal cord, and shoulder blades of the subject appear to have been replaced with artificial versions of unknown make and metal.

Subject only takes notice of this when it is pointed out, and states that it has no knowledge of how, why, or when these replacements took place, stating it had had them as long as it could remember. There is a symbol engraved into the forehead of the subject, which appears to be of Sumerian origin. Symbol has of yet been untranslated, and subject appears distressed when the symbol is mentioned at all, refusing to speak on it.

Subject does need to eat and drink on a regular basis, but is strictly carnivorous owing to its effect on plant-based items.

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SCP, who refers to itself as "Cain", is generally polite and genial to all who speak to it, though it has been described as being cold and somewhat mechanical in its speech. It is very helpful, and enjoys aiding personnel in their daily actions, whatever they may be.

It has highly detailed knowledge of ancient to recent events in history, and most commonly spoken languages in the world, including ones that have since died out. Subject has professed to having a photographic memory, remembering word-for-word all text in an eight-hundred-page dictionary that was flicked through in a minute and a half.

It has scored above average in all intelligence tests given to it. SCP's presence is inimical to any and all life grown in soil, causing death to any such life within a twenty 20 meter radius. Any land SCP has walked on and any within the twenty [20] meter radius becomes barren as all anaerobic bacteria dies, rendering the soil incapable of supporting life until new bacteria are introduced. Anything that is derived from soil-grown life, such as wood and paper, immediately rots and disintegrates upon touch of SCP Further affected derivatives include anything hydroponically grown.

This applies to any damage directed at SCP Attempts to get tissue and blood samples have proven futile: when the procedure was initiated, personnel carrying out the action felt the sensation of whatever was applied to SCP, and wound up with a sample of their own blood or tissue, despite the fact that ''all actions were directed solely at SCP''.

Indirect damage through a medium also results in the person perpetrating the action receiving the wounds caused. Although SCP receives no actual harm from damage to its person, it has stated that it still feels the pain of the action, and has politely asked researchers to abstain from overly harmful actions to its person.

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SCP told police members that the gang had attempted to make sport of it, but became angry and attempted to kill SCP, resulting in their own demise.How to Subscribe and List of All Episodes.

I mean in the actual practice of healthcare, not the cost or doctor shortages, but what medical professionals do on the job. Enter Dr. Stephen Trzeciak.

He works as an intensivist — the doctor who treats patients in intensive care. He said he felt intuitively that detachment was probably the wrong thing to do. Trzeciak tells the story of a highway crash in Sweden: two buses collided head-on. Amazingly, only six people were killed; 56 were saved. Researchers followed up with those 56 people five years later to ask what they specifically remembered of their ordeal.

Two things stood out as their strongest memories. The first thing, no surprise: pain.

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The second thing: a lack of compassion from the people who cared for them during their hospitalization. Being a research geek, he dove into the studies: there are a lot of studies about compassion in a medical setting.

He reviewed more than a thousand study summaries, and read in detail the studies that stood out to him — around of them. He found that two-thirds of patients surveyed by researchers said they could think of a medical encounter where they felt no compassion at all from their doctor. As he read study after study, it was obvious they formed a very strong conclusion: compassion does matter — a lot. Not just because of the moral imperative, but it turns out that the effect on healthcare providers of expressing compassion for their patients is significant: it leads to more attentive and effective care, which obviously benefits patients.

In fact, studies of compassion find the patients have much better medical outcomes if they feel their doctors actually care. So researchers studied that, too. The results are stunning: it only takes 40 seconds to let the patients know their doctor understands that this is a scary and stressful time, that he or she will work hard to get them through it, and will be there for them. All that actually only took 35 seconds in the study. They used rigorous study protocols: a randomized, controlled trial with actual doctors and patients.

And the answer was just 40 seconds! Especially when it leads to significantly improved outcomes? But the real clincher is, the doctors benefit too, with reduced stress, better health, and less burnout.

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After reading that study, Dr. Maybe, he thought, doctors could benefit as much as the patients to ease their burnout.This Notice announces the availability of administrative supplements to active grants that focus on biomedical software development or have a significant software development component. The goal of these supplements is to invest in research software tools with recognized value in a scientific community to enhance their impact by leveraging best practices in software development and advances in cloud computing.

Through these awards, the NIH Office of Data Science Strategy ODSS intends to help researchers who have developed scientifically valuable software to make tools sustainable, contribute to open science, and take advantage of new data science and computing paradigms. As part of their research projects, investigators often produce innovative, scientifically valuable software tools. The tools have enabled scientists to efficiently process and manage data, mine, analyze, visualize, and interpret results.

However, much of this valuable software has been built and supported under conditions that are no longer optimal in a rapidly changing landscape. Additionally, investigators lack the resources to adapt and revise the software to take advantage of new computing paradigms and to be robust, sustainable, and accessible to a broader community. This opportunity is intended to help researchers redeploy these research software tools to be robust and sustainable in a shared data ecosystem envisioned by the NIH ODSS.

The challenges are considerable. For example, many tools were developed and customized for data held on-premises, often optimized for local computing platforms including the supporting libraries and cannot be readily scaled or applied to open science data, such as those stored in a cloud environment. Software tools have most often been developed in academic settings in absence of input from research software engineers who can aid in this transition to operational efficiency and sustainability.

There have been few practical ways to support joint efforts between researchers and software engineers with skills to develop and revise research tools for robust design, accessibility and scalability on modern computing platforms.

The traditional grant funding process has emphasized innovation for research progress over the use of software engineering best-practices and design principles, which are essential for reliability and sustainability in an era of large-scale, integrated data. It is the NIH vision to establish a modernized and integrated biomedical data ecosystem that adopts the latest data science technologies, including cloud computing, and best practice guidelines arising from community consensus, such as the FAIR principles and open-source development.

In addition to major efforts in IT infrastructure, data resources, workforce development, and policy considerations, the data science strategic plan includes goals to enhance software and workflows for the modern data ecosystem.

The goal of this Notice of Special Interest NOSI is to encourage researchers to engage in new types of collaborations that focus on research software. Supplements will support efforts that address robustness, sustainability, reusability, and scalability of existing biomedical research software tools and workflows of recognized scientific value.

These efforts are expected to adhere to software engineering best practices and design principles and take significant steps toward sustainability in open source cloud-based environments.

A broad range of projects that have significant biomedical research software or workflow development components are eligible, regardless of the scientific area of emphasis. The scope of each proposed project is defined by and limited to the aims of the funded project for which the supplement is being sought. Significant software engineering skills are expected to be needed to develop robust implementations and to adapt the software to changing computing paradigms.

Thus, the supplements are primarily intended to provide support for software engineering staff and storage and computing costs that are required to test software revisions.

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Delivering reliable, sustainable, and reusable software across multiple platforms is a whole-lifecycle effort, as illustrated in the following examples. Software development can be improved with enhancements to the development environment, including resources for building, testing, and community contribution. Engaging the community can improve robustness by making code available with appropriate open source licensing. Compliance with open interfaces and data formats can be added to enhance interoperability and reusability.

Refactoring can be performed to take advantage of new hardware or compute environments e. Reusability can be enhanced by improving dissemination channels for important algorithms and tools e. Projects can propose to test cloud-readiness in a local, commercial, or public cloud environment. Cloud readiness is a blanket term that can encompass a range of activities.

In this announcement cloud readiness refers to adapting to cloud architecture and extending the usefulness of software. Examples to produce robust, sustainable or cloud-ready research software include, but are not limited to:. The supplement application must demonstrate the use of best software engineering practices and design principles.

Examples of relevant projects that address one or more of the challenges toward becoming ready for open science and cloud environment include, but are not limited to:. Possible exceptions include enhanced data security and privacy functions.

To be eligible, the parent award must be able to receive funds in FY Oct. The number of awards will be contingent on availability of funds and receipt of meritorious applications.

It is currently anticipated that awards will be made. Submitted applications must follow the guidelines of the IC that funds the parent grant.

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Administrative Supplements do not receive peer review.On hunts, they are extended to ensnare and immobilize prey. Y It has 80 tentacles that move about freely. They can sting, causing poisoning and sharp, stabbing pain. Omega Ruby Tentacruel has large red orbs on its head. The orbs glow before lashing the vicinity with a harsh ultrasonic blast. Alpha Sapphire Tentacruel has tentacles that can be freely elongated and shortened at will. It ensnares prey with its tentacles and weakens the prey by dosing it with a harsh toxin.

It can catch up to 80 prey at the same time. The more HP the target has, the greater this attack's power. This may also poison the target. It may confuse the target. It may also lower the target's Speed stat.

The acid may also lower the targets' Sp. Def stats. They poison opponents that switch into battle. It may also lower their Speed stats. This harshly reduces the target's Sp. Def stat. It may also confuse the target. It may also poison the target.


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